Your personal life, your professional life, and your creative life are all intertwined. I went through a few very difficult years where I felt like a failure. But it was actually really important for me to go through that. Struggle, for me, is the most inspirational thing in the world at the end of the day - as long as you treat it that way.
I would say that nobody is going to work harder for your career than yourself - the one with the vision. No matter how many people you hire, nobody is going to get is as much as yourself does. So it's really important to be your own leader at all times and not hand it all off, otherwise the whole empire will fall apart.