Helping people boost themselves out of poverty is the best way to make a lasting positive difference in a person's life.
Great entrepreneurs focus intensely on an opportunity where others see nothing. This focus and intensity helps to eliminate wasted effort and distractions. Most companies die from indigestion rather than starvation, i.e., companies suffer from doing too many things at the same time rather than doing too few things very well.
Go where your customers take you! For example, did you know that Sony's first product was a rice cooker? Since abandoning the rice cooker, it has merely managed to become the world's biggest consumer electronics company.
Philanthropy without scale and sustainability is like any other bad business that will simply wither and die on the vine.