I can say with pride verging on smugness that I've got two very successful shows that assume their audience is very smart.
I can't see what's wrong about assuming intelligence in your audience and what's bad news about being rewarded for assuming that.
When you're surrounded by friends and exes, there's a whole lot of stuff that starts crawling out. But however serious and traumatic those experiences may be to the participant, to the onlooker they're hilarious.
I know this is going to sound very self-serving, and I apologize for it, but if you can write comedy, you can pretty much write anything, because it's the hardest. It's the most technically demanding, the most precisely evaluated form of writing. People know if it works or not. There's a big button marked 'fail,' and that's when nobody laughs.