Genre might certainly increase some of your narrative freedoms, but it also diminishes others. That's the nature of genre.
Our U.S. audience is composed of globally-minded Americans, an elite category, the ones who do have passports, the decision-makers, senior ranks in the administration, senators on Capitol Hill.
I have heard of people dying from prostate cancer, and they are the unlucky ones, the people who didn't know they had got it, and it went on the rampage.
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