To my mathematical brain, the numbers alone make thinking about aliens perfectly rational. The real challenge is to work out what aliens might actually be like.
So long as the universe had a beginning, we could suppose it had a creator. But if the universe is really completely self-contained, having no boundary or edge, it would have neither beginning nor end: it would simply be. What place, then, for a creator?
Our population and our use of the finite resources of planet Earth are growing exponentially, along with our technical ability to change the environment for good or ill.
I can't say that my disability has helped my work, but it has allowed me to concentrate on research without having to lecture or sit on boring committees.